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GLP-1 also discourages the liver from producing too much sugar. Glipizide is 98–99% bound to serum proteins, primarily to albumin. Because of the way they work, side effects of BASs can include flatulence and constipation. Troglitazone sometimes causes fluid retention and weight gain. Many other medications, such as sulfonylureas, meglitinides and others, may cause hypoglycemia when used alone to treat diabetes. No prospective studies have compared the costs and savings for optimal oral therapy versus no pharmacologic.

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Rosiglitazone (Avandia) and pioglitazone (ACTOS) are in a group of drugs called thiazolidinediones.

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